肖武生

心血管和呼吸系統疾病是影響人群健康的主要疾病🗂，其發生與危害和環境汙染密切相關。本課題組圍繞能量代謝和氧化還原穩態兩大機製，探究環境危害暴露（1）如何導致心肺血管損傷和（2）如何加劇心肺血管疾病的風險。

課題一：能量代謝與心肺血管損傷和疾病

能量代謝是維持所有生命活動的基礎機製。代謝紊亂可導致心肺血管疾病等眾多疾病和不良健康結局的發生與發展。我們致力於研究細胞代謝通路和代謝物水平改變對環境因素（如重金屬和新汙染物等）致心肺血管系統毒性的調控機製和防治。

課題二🧫：氧化還原應激與心肺血管損傷和疾病

氧化還原穩態是由細胞的抗氧化（抗氧化酶和非酶類抗氧化劑）和促氧化體系（氧自由基和氮自由基）共同精細維持☑️。兩大體系失衡將引起氧化應激和還原應激，兩者均可造成細胞功能損傷🙇🏿‍♀️𓀚。我們致力於研究環境汙染物暴露如何打破氧化還原體系的平衡，導致心肺血管系統氧化和還原損傷👩🏼‍🍼🎂。

1. 主持北京市自然基金面上項目（7252186；2025-2027）：糖酵解酶PFKFB3調控鎘致血管內皮早期損傷的免疫代謝機製

2. 主持中國CDC環境與人群健康重點實驗室開放基金項目（2024-CKL-02；2024-2026）：芳烴受體調控鎘致血管內皮早期損傷的免疫代謝機製

3. 主持山西醫科大學煤炭環境致病與防治教育部重點實驗室開放基金項目（MEKLCEPP/SXMU-201413🌏；2024-2026）：礦區環境水平相當的鎘暴露致肺纖維化的免疫代謝機製

4. 主持意昂体育平台臨床醫學+X青年專項（PKU2023LCXQ005；2023）🧑🏻‍🔧：KLF4調控肺動脈高壓的免疫代謝機製研究

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2. Xiao W, Oldham WM, Priolo C, Pandey AK, Loscalzo J. Immunometabolic endothelial phenotypes: integrating inflammation and glucose metabolism. Circulation Research. 2021, 129: 9-29.

3. Cui K, Li L, Li K, Xiao W*, Wang Q*. AOP-based framework for predicting the joint action mode of di-(2-ethylhexyl) phthalate and bisphenol A co-exposure on autism spectrum disorder. Neurotoxicology. 2024, 104: 75-84.（*共通訊作者）

4. Li K, Zhang Y, Li L, Cui K, Li Y, Li C, Dai Y*, Xiao W*, Wang Q*. Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study. Food and Chemical Toxicology. 2024, 188: 114686.（*共通訊作者）

5. Xiao W and Loscalzo J. Metabolic response to reductive stress. Antioxidants & Redox Signaling. 2020, 32: 1330-1347.（ESI高引論文）

6. Xiao W, Wang RS, Handy DE, Loscalzo J. NAD(H) and NADP(H) redox couples and cellular energy metabolism. Antioxidants & Redox Signaling. 2018, 28: 251-272.（ESI高引論文）

7. He H, Mulhern RM, Oldham WM, Xiao W, Lin Y, Liao R, Loscalzo J. L-2-hydroxyglutarate protects against cardiac injury via metabolic remodeling. Circulation Research. 2022, 131: 562-579.

8. Pandey A, Waldeck-Weirmair M, Wells Q, Xiao W, Yadav S, Eroglu E, Michel T, Loscalzo J. Expression of CD70 modulates nitric oxide and redox status in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022, 42: 1169-1185.

9. Xiao W, Sarsour EH, Wagner BA, Doskey CM., Buettner GR, Domann FE, Goswami PC. Succinate dehydrogenase activity regulates PCB3-quinone induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Archives of Toxicology. 2016, 90: 319-332.

10. Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone induced oxidative stress and toxicity in human keratinocytes. Free Radical Biology and Medicine. 2013, 65: 70-77.